T-2 Toxin-Induced Morphological Changes in Pregnant Rats
نویسندگان
چکیده
منابع مشابه
T-2 Toxin-induced Toxicity in Pregnant Mice and Rats
T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably secondary to the inhibition of protein synthesis. In ad...
متن کاملIn vitro metabolism of T-2 toxin in rats.
T-2 toxin was rapidly converted in the 9,000 X g supernatant fraction of rat liver homogenate into HT-2 toxin, T-2 tetraol, and two unknown metabolites designated as TMR-1 and TMR-2. TMR-1 was characterized as 4-deacetylneosolaniol (15-acetoxy-3 alpha, 4 beta, 8 alpha-trihydroxy-12,13-epoxytrichothec-9-ene) by spectroscopic analyses. Since the same metabolites were also obtained from HT-2 toxin...
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15 صفحه اولStudy on the Apoptosis Mechanism Induced by T-2 Toxin
T-2 toxin is known to induce apoptosis in mammalian cells. The mechanism of apoptosis induced by T-2 toxin has been proposed to be linked with oxidative stress and mitochondrial pathway. In the current study, the toxic effect of T-2 on Hela, Bel-7402, and Chang liver cells was examined in dose-dependent and time-dependent manner by MTT assay. Caspase-3 was found to be up-regulated under T-2 tox...
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objective: amiodarone as an iodinated benzofuran derivative is a potent antiarrhythmic agent currently used for the treatment of ventricular arrhythmias. pulmonary toxicity is one of the complications of amiodarone therapy. the aim of this study was to determine the toxicity of amiodarone for pneumocytes. materials and methods: 14 male white new zealand rabbits were divided in a control group a...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 2003
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.16.59